Genistein Induces Pancreatic -Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice
نویسندگان
چکیده
Department of Human Nutrition, Foods, and Exercise (Z.F., W.Zha., W.Zhe., D.L.), College of Agriculture and Life Sciences, and Virginia Bioinformatics Institute (J.B.-R.), Virginia Polytechnic Institute and State University, and Edward Via College of Osteopathic, College of Medicine (Z.J., H.M.), Blacksburg, Virginia 24061; Department of Pharmacology (H.L.), Rush University Medical Center, Chicago, Illinois 60612; Department of Internal Medicine (J.N.), Eastern Virginia Medical School, Norfolk, Virginia 23501; and Institute for Nutrisciences and Health (Y.W.), National Research Council Canada, Ottawa, Canada K1A 0R6
منابع مشابه
Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice.
Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. However, studies on whether genistein has an effect on pancreatic beta-cell function are very limited. In the present study, we investigated the effect of genistein on beta-cell proliferation and cellular signaling related to this effect and further determined its antidiabetic potential in insulin-defic...
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